Naqvi Lab Quantitative principles of gene regulation in development and disease

Research

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We seek to understand the quantitative control of gene expression in development and the resulting “tipping points” in disease, knowledge that can lead to more precise, controlled therapies for a range of rare and common disorders.

To achieve these goals, we combine functional genomics and computational modeling using stem cell-derived in vitro models of development. A common theme across projects is the use of highly quantitative tools and approaches: “analog genomics”.

Team

Key publications

dubTAGs enable on-demand stabilization for tunable and reversible control of endogenous protein levels
Sunil Guharajan*, Xiangyang Song*, Qiong Wu, Sachi Sengupta, Wenyi Wei, Yan Xiong*, Jian Jin*, Sahin Naqvi*
bioRxiv   ·   18 Sep 2026   ·   doi:10.64898/2026.09.11.751045
Transfer learning reveals sequence determinants of the quantitative response to transcription factor dosage
Sahin Naqvi, Seungsoo Kim*, Saman Tabatabaee*, Anusri Pampari, Anshul Kundaje, Jonathan K. Pritchard, Joanna Wysocka
Cell Genomics   ·   01 Mar 2025   ·   doi:10.1016/j.xgen.2025.100780
Precise modulation of transcription factor levels identifies features underlying dosage sensitivity
Sahin Naqvi, Seungsoo Kim, Hanne Hoskens, Harry S. Matthews, Richard A. Spritz, ..., Benedikt Hallgrímsson, Tomek Swigut, Peter Claes, Jonathan K. Pritchard, Joanna Wysocka
Nature Genetics   ·   06 Apr 2023   ·   doi:10.1038/s41588-023-01366-2
Shared heritability of human face and brain shape
Sahin Naqvi*, Yoeri Sleyp*, Hanne Hoskens, Karlijne Indencleef, Jeffrey P. Spence, ..., Jonathan K. Pritchard, Stefan Sunaert, Hilde Peeters, Joanna Wysocka, Peter Claes
Nature Genetics   ·   05 Apr 2021   ·   doi:10.1038/s41588-021-00827-w

Affiliations